The December issue of Smithsonian introduces the American Ingenuity Awards. dream hampton profiles Grammy Award winner Esperanza Spalding. Abigail Tucker on the high school sophomore who invented a new way to test for a deadly form of cancer and how one legal crusader is giving young people in America’s prisons a second chance.

Congratulations to 2011 Science Fellow Pardis Sabeti, recipient of the Smithsonian American Ingenuity Award for natural sciences. See Sabeti explain how her study of genomes has revealed a new approach to treating infectious diseases.

Congratulations to 2009 Social Innovation Fellow Jason Aramburu of re:char for winning €200,000 in the Dutch Postcode Lottery’s Green Challenge. The Dutch Postcode Lottery presents the Postcode Lottery Green Challenge to encourage and aid the invention of great new green products and services.

Previous winners include another 2009 PopTech Social Innovation Fellow, Eben Bayer